San Francisco 49ers Schedule
23 games
| Date | Opponent | Time | Result |
|---|---|---|---|
| Aug 09, 2025 | vs Denver Broncos vs DEN | 8:30 PM ET | Scheduled |
| Aug 16, 2025 | @ Las Vegas Raiders @ LV | 8:05 PM ET | W 22-19 |
| Aug 23, 2025 | vs Los Angeles Chargers vs LAC | 8:30 PM ET | Scheduled |
| Sep 07, 2025 | @ Seattle Seahawks @ SEA | 4:05 PM ET | Scheduled |
| Sep 14, 2025 | @ New Orleans Saints @ NO | 1:00 PM ET | Scheduled |
| Sep 21, 2025 | vs Arizona Cardinals vs ARI | 4:25 PM ET | Scheduled |
| Sep 28, 2025 | vs Jacksonville Jaguars vs JAX | 4:05 PM ET | L 21-26 |
| Oct 02, 2025 | @ Los Angeles Rams @ LAR | 8:15 PM ET | Scheduled |
| Oct 12, 2025 | @ Tampa Bay Buccaneers @ TB | 1:00 PM ET | Scheduled |
| Oct 19, 2025 | vs Atlanta Falcons vs ATL | 8:20 PM ET | Scheduled |
| Oct 26, 2025 | @ Houston Texans @ HOU | 1:00 PM ET | Scheduled |
| Nov 02, 2025 | @ New York Giants @ NYG | 1:00 PM ET | Scheduled |
| Nov 09, 2025 | vs Los Angeles Rams vs LAR | 4:25 PM ET | Scheduled |
| Nov 09, 2025 | vs Los Angeles Rams vs LAR | 4:25 PM ET | Scheduled |
| Nov 16, 2025 | @ Arizona Cardinals @ ARI | 4:05 PM ET | Scheduled |
| Nov 16, 2025 | @ Arizona Cardinals @ ARI | 4:05 PM ET | Scheduled |
| Nov 24, 2025 | vs Carolina Panthers vs CAR | 8:15 PM ET | Scheduled |
| Nov 30, 2025 | @ Cleveland Browns @ CLE | 1:00 PM ET | Scheduled |
| Dec 14, 2025 | vs Tennessee Titans vs TEN | 4:25 PM ET | Scheduled |
| Dec 22, 2025 | @ Indianapolis Colts @ IND | 8:15 PM ET | Scheduled |
| Dec 28, 2025 | vs Chicago Bears vs CHI | 8:20 PM ET | Scheduled |
| Jan 03, 2026 | vs Seattle Seahawks vs SEA | 8:00 PM ET | Scheduled |
| Jan 11, 2026 | @ Philadelphia Eagles @ PHI | 4:30 PM ET | Scheduled |